Initial Ecological Risk Assessment of 1,2-Benzisothiazol-3-one in Environment
نویسندگان
چکیده
منابع مشابه
Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors.
A number of 1,2-benzisothiazol-3-one derivatives were prepared through structural modification of the original compound from high-throughput screening. Some analogues (e.g., 6b, 6r, 6s and 6w) were identified as novel and potent caspase inhibitors with IC50 of nanomolar. Structure-activity relationship (SAR) studies for caspase-3 inhibition were evaluated in vitro. Molecular modeling studies pr...
متن کاملEcological risk assessment of heavy metals from cement factory dust
Background: The release of metals from industrial factories is one of the most important sources of environmental pollution. The present study aimed to determine the concentration of heavy metals like cadmium (Cd), chromium (Cr), manganese (Mn), nickel (Ni), and lead (Pb) in dust around the cement factory. Methods: A total of 22 dust samples were collected from areas around the cement factory...
متن کاملEcological risk assessment of heavy metals in landfill soil of Tehran and its adjacent residential area
Background and Objective: Landfills as municipal solid waste are considered as the source of pollution. The present study aimed to assess the ecological risk of heavy metals in Tehran landfill soil and the adjacent residential area. Materials and Methods: Having consulted with the specialists and considered the waste processing facilities, 12 sampling points were selected and sampled in four s...
متن کاملQSAR Analysis for Some 1, 2-Benzisothiazol-3-one Derivatives as Caspase-3 Inhibitors by Stepwise MLR Method
Caspase-3, one of the dominant effectors caspases, is activated in almost every model of apoptosis with various signaling pathways. Hence, inhibition of caspase-3 has become an attractive target in the treatment of neurodegenerative diseases. Caspase-3 inhibitory activities of some 1,2-benzisothiazol-3-one derivatives were modeled by quantitative structure–activity relationship (QSAR) using ste...
متن کاملAssessment of the distribution, bioavailability and ecological risk assessment of heavy metals in the coastal sediments of Qeshm Island (Hormozgan)
Sediment samples were collected from 8 sites in the northern areas of Qeshm Island, Iran to determine the total and partial concentrations of heavy metals including copper (Cu), lead (Pb), nickel (Ni), cadmium (Cd), and Iron (Fe), in February 2016. A combination of nitric acid and perchloric acid was used to determine the total concentrations and sequential extraction method was used to analyze...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Korean Society of Environmental Engineers
سال: 2013
ISSN: 1225-5025
DOI: 10.4491/ksee.2013.35.3.165